Comparison Efficacy of Mirogabalin and Pregabalin in Total Knee Arthroplasty. a Randomized Controlled Trial
Status: Recruiting
Location: See location...
Intervention Type: Drug
Study Type: Interventional
Study Phase: Not Applicable
SUMMARY
The goal of this RCT is to compare efficacy between mirogabalin and pregabalin in pain reducing after unilateral primary total knee arthroplasty. The main question\[s\] it aims to answer are: • Does mirogabalin have better pain reduction than pregabalin after unilateral primary total knee arthroplasty. Participants will randomized to mirogabalin or pregabalin group and will take the drug for 6 weeks after TKA. Researchers will compare to pregabalin group to see pain and functional outcomes after TKA.
Eligibility
Participation Requirements
Sex: All
Minimum Age: 50
Maximum Age: 85
Healthy Volunteers: f
View:
• Age 50-85 years old
• Unilateral primary osteoarthritis undergoing primary TKA
• ASA I-III
Locations
Other Locations
Thailand
Thammasat University Hospital
RECRUITING
Khlong Luang
Contact Information
Primary
Yot Tanariyakul, M.D.
y.tanariyakul@gmail.com
+66863930257
Time Frame
Start Date: 2024-04-01
Estimated Completion Date: 2025-05-31
Participants
Target number of participants: 80
Treatments
Experimental: Mirogabalin
Participants will receive 5 mg of mirogabalin, taken as half a tablet, every day twice a day, after breakfast and dinner, for 6 weeks.
Active_comparator: Pregabalin
Participants will receive 50 mg of pregabalin, taken as a tablet, every day twice a day, after breakfast and dinner, for 6 weeks.
Related Therapeutic Areas
Sponsors
Leads: Thammasat University Hospital